|
iDEA: Drexel E-repository and Archives >
Drexel Academic Community >
College of Arts and Sciences >
Department of Physics >
Faculty Research and Publications (Physics) >
From simulation to therapy: a systems biology approach to oncogene detection
Please use this identifier to cite or link to this item:
http://hdl.handle.net/1860/1133
|
| Title: | From simulation to therapy: a systems biology approach to oncogene detection |
| Authors: | Ghosh, Avijit
Pant, Dhruv
Kumar, Aparna
Zou, Rui
Miller, David L. |
| Keywords: | Multi Protein Complexes
Nanostructures
Protein Folding
Cellular systems |
| Issue Date: | 9-Jun-2006 |
| Publisher: | John von Neumann Institute for Computing (NIC) |
| Citation: | Paper presented at From Computational Biophysics to Systems Biology, Forschungszentrum Jülich, Jülich, Germany. |
| Abstract: | In silico models of signal transduction pathways have been successful both qualitatively as well
as quantitatively in describing how complex protein networks control cell function. Moreover,
the study of networks has been used to elucidate not only how these pathways control the complex
regulation and response mechanism of cells, but also provide insight into how a breakdown
in the biological circuitry can lead to particular disease states.
We have recently examined the circuitry within the MAPK signal transduction pathway to understand
how changes within this canonical network may lead to malfunction, notably the rise
of proto-oncogenic cells. In addition we have developed a new complementary technique that
provides insight into which key players within the pathway are most likely to be most conducive
to selective inhibition within this transformed line of cells. These tools have been made freely
available to the public, as part of a software suite developed by our group, Cellsim1. I will give
an overview on how Cellsim may be used to quantitate cell function and moreover malfunction. |
| Description: | The goal of the workshop in which this paper was presented was to bring together expertise from physics, biology, and computer science to discuss current trends in computational biophysics and systems biology. http://www.fz-juelich.de/conference/cbsb06/ |
| URI: | http://hdl.handle.net/1860/1133 |
| Appears in Collections: | Faculty Research and Publications (Physics)
|
Items in iDEA are protected by copyright, with all rights reserved, unless otherwise indicated.
|
www.drexel.edu
