|
iDEA: Drexel E-repository and Archives >
Drexel Academic Community >
School of Biomedical Engineering, Science & Health Systems >
Faculty Research and Publications (Biomed Eng) >
Interaction between rhythms in the human basal ganglia: application of bispectral analysis to local field potentials
Please use this identifier to cite or link to this item:
http://hdl.handle.net/1860/2697
|
| Title: | Interaction between rhythms in the human basal ganglia: application of bispectral analysis to local field potentials |
| Authors: | Marceglia, Sara
Bianchi, Anna Maria
Baselli, Giuseppe
Foffani, Guglielmo
Cogiamanian, Filippo
Modugno, Nicola
Mrakic-Sposta, Simona
Priori, Alberto
Cerutti, Sergio |
| Keywords: | Basal Ganglia
Bispectral Analysis
Deep Brain Stimulation
Dystonia
Parkinson’s Disease |
| Issue Date: | Dec-2007 |
| Publisher: | Institute of Electrical and Electronics Engineers (IEEE) |
| Citation: | IEEE Transactions on Neural Systems and Rehabilitation Engineering, 15(4): pp. 483-492. |
| Abstract: | The application of deep brain stimulation (DBS) for
the treatment of Parkinson’s disease offered a direct “insight” into
the human electrical activity in subcortical structures. The analysis
of the oscillatory activity [local field potentials (LFPs)] disclosed the
importance of rhythms and of interactions between rhythms in the
human basal ganglia information processing. The aim of this study
wasto investigate the existence of possible nonlinear interactions between
LFP rhythms characterizing the output structure of the basal
ganglia, the globus pallidus internus, by means of bispectral analysis.
The results of this study disclosed that the rhythms expressed in
the globus pallidus internus of the untreated parkinsonian patient
are not independent and, in particular, the low-beta (13–20Hz)band
generates harmonics that are included in the high-beta (20–35 Hz)
band. Conversely, in the dystonic globus pallidus, as well as in the
parkinsonian globus pallidus afterdopaminergic medication (i.e., in
the more “normal” condition), the rhythms are substantially independent
and characterized by a strong activity in the low-frequency
band that generates a second harmonic (4–14 Hz), mostly included
in the same band. The interactions between rhythms in the human
globus pallidus are therefore different in different pathologies and
in different patient’s states. The interpretation of these interactions
is likely critical for fully understanding the role of LFP rhythms in
the pathophysiology of human basal ganglia. |
| URI: | http://dx.doi.org/10.1109/TNSRE.2007.907893
http://hdl.handle.net/1860/2697 |
| Appears in Collections: | Faculty Research and Publications (Biomed Eng)
|
Items in iDEA are protected by copyright, with all rights reserved, unless otherwise indicated.
|
www.drexel.edu
