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Please use this identifier to cite or link to this item: http://hdl.handle.net/1860/2723

Title: A systems approach for the prediction of wild type MAPK pathway response to targeted drugs
Authors: Miller, David J.
Ghosh, Avijit
Issue Date: Oct-2007
Citation: Paper presented at the Eighth International Conference on Systems Biology, Long Beach, CA.
Abstract: In this paper we simulate the wild type MAPK pathway response to twelve in silico drugs that were previously found to reduce elevated phosphorylated ERK levels (ERK*) in 40 top ranked mutations in a model of the MAPK signal transduction pathway. We nd that a subset of the simulated drugs (notably those targeting GEF and the G G-protein trimer) were able to e ectively inhibit the elevated ERK* levels of the mutated pathways, whilst simultaneously eliciting only minimal inhibition of the wild type pathway ERK* response to EGF stimulation.
URI: http://hdl.handle.net/1860/2723
Appears in Collections:Faculty Research and Publications (Physics)

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