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Homogenization of heterogeneous tissue scaffold: A comparison of mechanics, asymptotic homogenization, and finite element approach
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http://hdl.handle.net/1860/802
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| Title: | Homogenization of heterogeneous tissue scaffold: A comparison of mechanics, asymptotic homogenization, and finite element approach |
| Authors: | Fang, Zhibin
Yan, Chang (Karen)
Sun, Wei
Shokoufandeh, Ali
Regli, William C. |
| Keywords: | Tissue engineering
tissue scaffold
homogenization
effective properties |
| Issue Date: | 2005 |
| Publisher: | Woodhead Publishing |
| Citation: | Journal of Bonic and Applied Biomechanics, 2005 Vol. 2 No. 1 pp. 17–29. Retrieved April 2006 from http://www.pages.drexel.edu/~sunwei/WSUN-Papers/ABBI-Paper.pdf |
| Abstract: | Actual prediction of the effective mechanical properties of tissue scaffolds is very important
for tissue engineering applications. Currently common homogenization methods are based on
three available approaches: standard mechanics modeling, homogenization theory, and finite element
methods. Each of these methods has advantages and limitations. This paper presents comparisons
and applications of these approaches for the prediction of the effective properties of a tissue scaffold.
Derivations and formulations of mechanics, homogenization, and finite element approach as they relate
to tissue engineering are described. The process for the development of a computational algorithm,
finite element implementation, and numerical solution for calculating the effective mechanical properties
of porous tissue scaffolds are also given. A comparison of the results based upon these different
approaches is presented. Parametric analyses using the homogenization approach to study the effects
of different scaffold materials and pore shapes on the properties of the scaffold are conducted, and the
results of the analyses are also presented. |
| URI: | http://hdl.handle.net/1860/802 |
| Appears in Collections: | Faculty Research and Publications (MEM)
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