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Targeting in situ and imaging multiple inflammatory biomarkers with quantum dots in DSS model of colitis
Please use this identifier to cite or link to this item:
http://hdl.handle.net/1860/961
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| Title: | Targeting in situ and imaging multiple inflammatory biomarkers with quantum dots in DSS model of colitis |
| Authors: | Karwa, Amolkumar
Papazoglou, Elisabeth S.
Pourrezaei, Kambiz
Tyagi, Som
Murthy, Sreekant |
| Keywords: | Biosensors
Biomarkers
Bioimaging
Bioinformatics |
| Issue Date: | 2006 |
| Citation: | Poster presented at Biomedical Technology Showcase 2006, Philadelphia, PA. Retrieved 18 Aug 2006 from http://www.biomed.drexel.edu/new04/Content/Biomed_Tech_Showcase/Poster_Presentations/Papazoglou_6.pdf. |
| Abstract: | Inflammatory Bowel Disease affects nearly 1.5 million people. Currently, there are no efficient and reliable methods to quantify the degree of inflammation in these patients. The objective here was to image and quantify in an experimental model of colitis, MPO, IL1_ and TNF_ (proinflammatory cytokines) using Quantum Dots (QDs) conjugated with specific antibodies. The resulting fluorescence intensity was then used as a measure of concentration of MPO and in turn inflammation. The fluorescent images obtained from animals showed sequential increase in fluorescence intensity of MPO correlating (R = 0.96) with clinical disease. Fluorescent images also showed co-localization of all the three markers in both acute as well as chronic inflammation. These observations suggest that QD bioconjugates can be used nanotools to image biomarkers of inflammation. |
| Description: | Item from the Biomedical Technology Showcase held July 20, 2006 at Drexel University's Bossone Research Enterprise Center. |
| URI: | http://hdl.handle.net/1860/961 |
| Appears in Collections: | Biomedical Technology Showcase, 2006
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